Magazine article Clinical Psychiatry News

Long-Term Use of Beta Carotene Beneficial

Magazine article Clinical Psychiatry News

Long-Term Use of Beta Carotene Beneficial

Article excerpt

PHILADELPHIA -- Long-term beta carotene supplementation could significantly reduce the risk of developing Alzheimer's disease, Francine Grodstein, Sc.D., reported at the 9th International Conference on Alzheimer's Disease and Related Disorders.

The findings come from the Physicians' Health Study II, a randomized trial of supplementation with beta carotene and other vitamins for chronic disease prevention in men.

In the Physicians' Health Study I, completed in the mid-1990s, no benefit was found among men who took 50 mg beta carotene every other day for prevention of either cardiovascular disease or cancer, said Dr. Grodstein, of Brigham and Women's Hospital and Harvard Medical School, Boston.

The second study involved 7,641 male physicians from the first study, who had begun taking beta carotene or placebo in 1982, plus 7,000 new recruits aged 50 and older, for whom randomization began in 1997.

Cognitive testing--including measures of general cognition, verbal memory, and category fluency--was conducted by telephone after a mean of 18 years in 4,049 of the continuous participants from the first study and in 1,904 of the new recruits after a mean of 1 year. …

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