Magazine article Clinical Psychiatry News

Paxil Fails to Improve Children's MDD

Magazine article Clinical Psychiatry News

Paxil Fails to Improve Children's MDD

Article excerpt

Paroxetine was no more effective than a placebo in reducing the symptoms of major depressive disorder in a population that, for the first time, included patients younger than 12 years, reported Dr. Graham J. Emslie of the University of Texas, Dallas, and his colleagues.

Overall, the average change from baseline on the Children's Depression Rating Scale-Revised (CDRS-R) was -22.58 points in patients who took paroxetine (Paxil) and -23.38 in a placebo group.

The randomized, double-blind, multicenter study of the effectiveness of paroxetine included an intent-to-treat population of 203 children aged 7-17 years who met the DSM-IV diagnostic criteria for major depressive disorder (J. Am. Acad. Child Adolesc. Psychiatry 2006;45:709-19).

The patients received either 10-50 mg/kg paroxetine daily or placebo for 8 weeks. The average age at diagnosis was 10 years, and about half of the patients in each group had experienced at least one prior major depressive disorder episode.

The dropout rate in the paroxetine group was significantly higher among children aged 7-11 years, compared with the placebo group (39% vs. …

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