Magazine article Clinical Psychiatry News

Results Mixed on Tiagabine for Insomnia

Magazine article Clinical Psychiatry News

Results Mixed on Tiagabine for Insomnia

Article excerpt

DENVER -- The anticonvulsant tiagabine (Gabitril) increased slow wave sleep in dose-dependent fashion in a 30-center randomized trial involving 232 adults with primary insomnia, James K. Walsh, Ph.D., reported at the annual meeting of the Associated Professional Sleep Societies.

But whether this drug-induced alteration in sleep architecture will translate into clinical utility for the treatment of insomnia remains an unanswered question. Of note, patients given tiagabine didn't report their sleep as being any deeper, more refreshing, or of better quality than patients on placebo, said Dr. Walsh, director of the sleep medicine and research center at St. Luke's Hospital, St. Louis.

Tiagabine is a selective [gamma]-aminobutyric acid (GABA) reuptake inhibitor that boosts synaptic GABA availability through selective inhibition of the GABA transporter-1 receptor.

The randomized trial compared four doses of tiagabine--4, 6, 8, and 10 mg at bedtime--and a placebo in a two-night polysomnographic study. …

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