ADHD Drug Dosage Cut by Behavioral Therapy: The Low Level of Side Effects Produced by Lower Doses Could Put Behavior Modification in the Spotlight

Article excerpt

WASHINGTON -- Behavior modification can reduce the level of medication needed in school-aged children with attention-deficit hyperactivity disorder, William E. Pelham Jr., Ph.D., said at the annual meeting of the Association for Behavioral and Cognitive Therapies.

Few studies have addressed the issue of how behavioral and pharmacologic therapies should be sequenced in children, said Dr. Pelham, a professor of pediatrics and psychiatry at the State University of New York, Buffalo.

Dr. Pelham and his colleagues have completed two studies funded by the National Institutes of Health that examined dosing and sequencing of behavior modification and medication. "We measured impairment--not core symptoms--because impairment is what you want to focus on; that is what causes the most problems for kids," said Dr. Pelham, who is also a professor of psychology at the university.

The first study included 154 children aged 5-12 years (130 boys and 24 girls) who participated in a summer day camp program. They were divided for 3 weeks into three behavior modification groups--no behavior modification, low-intensity behavior modification, and high-intensity behavior modification. In addition, the children were divided into four dosage groups for methylphenidate (placebo, 0.15 mg/kg, 0.3 mg/kg, and 0.6 mg/kg, three times daily).

Medication was randomized each day, and the program counselors recorded the children's behavior in areas such as failing to comply with staff requests, following activity rules, and exhibiting conduct problems.

When the data were reviewed at summer's end, the lowest dose of medication--0.15 mg/kg three times daily--had a surprising and substantial effect on reducing ADHD impairment. In fact, the maximum incremental value of medication to behavior modification occurred at this low dose.

"There was no incremental value for most children beyond the 0.15-mg/kg dose in combination with behavior modification, but the highest dose--0.6 mg/kg--produced the largest effects in the absence of behavior modification," Dr. Pelham said. This dosage normalized the largest number of children when combined with behavior modification. The effects of behavior modification alone and medication alone were comparable.

"Medication alone does not normalize the children's performance," he explained. "Even at the highest dose of 0.6 mg/kg three times daily, many children were not normalized; the effect of behavior modification is as strong as the effect of medication." Lower doses produce a substantially lower level of side effects--a benefit of using behavior modification as the first-line intervention. …

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