Magazine article Clinical Psychiatry News

Glycemic Control and Weight Gain Not Inevitable

Magazine article Clinical Psychiatry News

Glycemic Control and Weight Gain Not Inevitable

Article excerpt

WASHINGTON -- A mathematical formula can be used to determine how many calories patients with type 2 diabetes must cut per day in order to avoid gaining weight when their high glucose levels are normalized with treatment, Scott Q. Siler, Ph.D., and Jeff K. Trimmer, Ph.D., reported in a poster at the annual scientific sessions of the American Diabetes Association.

Reduction in glycosuria is an important reason that patients with diabetes often gain weight as their hyperglycemia is reduced with treatment. The phenomenon is seen most often with insulin, thiazolidine-diones, meglitinides, and sulfonylureas. Weight gain can be minimized, however, by counseling patients in advance about caloric reduction, said Dr. Siler and Dr. Trimmer, of Entelos Inc., Foster City, Calif.

Using the Entelos Metabolism PhysioLab platform, a mathematical model of whole-body human metabolism, a total of 133 "virtual" patients with type 2 diabetes were modeled for the effects of treatment with pioglitazone (45 mg/day), subcutaneous insulin (40 U 70/30 regular or lente twice daily), or nateglinide (120 mg three times daily). None of the virtual patients had impaired renal function.

The first study involved 117 patients with a mean hemoglobin [A. …

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