Magazine article Clinical Psychiatry News

High Folate Intake May Lower AD Risk

Magazine article Clinical Psychiatry News

High Folate Intake May Lower AD Risk

Article excerpt

High intake of folate decreased the risk of Alzheimer's disease in a predominantly Hispanic and African American cohort of elderly people, according to a recently published study.

There was a statistically significant association between AD risk and combined dietary and supplemental folate consumption, but not between AD and either type of folate alone, suggesting that cumulative intake from both sources is important in assessing Alzheimer's risk, wrote Dr. Jose A. Luchsinger of Columbia University, New York, and his associates.

These results are consistent with those of several previous studies of folate and AD risk, but conflict with the results of several others. "Definitive conclusions about the value of higher folate intake in the prevention of AD cannot be made at this time," Dr. Luchsinger and his associates said, adding that "the decision to increase folate intake to prevent AD should await clinical trials."

In what they described as the first published study of the issue in a cohort that was predominantly black and Caribbean Hispanic, the researchers assessed diet and cognitive status in 965 subjects in 1992-1994 and thereafter at 18-month intervals. …

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