Magazine article Clinical Psychiatry News

High Midlife Cholesterol Increases Alzheimer's Risk

Magazine article Clinical Psychiatry News

High Midlife Cholesterol Increases Alzheimer's Risk

Article excerpt

CHICAGO -- High cholesterol levels in midlife are associated with an increased risk of Alzheimer's disease and vascular dementia, data from a large, diverse cohort suggest.

The analysis of more than 9,500 people showed that those patients with midlife total cholesterol levels of 249-500 mg/dL were one-and-a-half times more likely to develop Alzheimer's than were patients with cholesterol levels less than 198 mg/dL (hazard ratio, 1.52), Dr. Alina Solomon and associates reported in a poster at the annual meeting of the American Academy of Neurology.

The risk of Alzheimer's was also significantly increased for patients with a history of cholesterol levels of 221-248 mg/dL (HR, 1.30), and those with levels of 198-220 mg/dL (HR, 1.18).

A similar pattern was observed for vascular dementia, with the risk of dementia significantly increased for patients with levels of 206-239 mg/dL (HR, 1.45). There was an upward trend among patients with levels of 239-500 mg/dL (HR, 1.22), but the number of patients was too small to reach statistical significance, said Dr. …

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