Magazine article Science News

Missing Enzyme Incites Cancer Debate

Magazine article Science News

Missing Enzyme Incites Cancer Debate

Article excerpt

Six generations of mutant mice have put a damper on one of the hottest areas in cancer research, although some scientists warn against a pessimistic rush to judgment.

The mice lack a component of telomerase, an enzyme that fastens short sequences of DNA to the ends of chromosomes. These so-called telomeres protect the tips and serve as buffers, since a bit of every chromosome tip is lost whenever cells divide (SN: 11/25/95, p. 362).

Except for the germ cells, which give rise to sperm and eggs, few adult human cells seem to produce telomerase. Yet most cancer cells do make the enzyme, prompting speculation that tumor cells need it to keep dividing. Consequently, many scientists have hailed the idea of inhibiting telomerase as a promising strategy for treating cancer.

That hypothesis is under fire now that a team of scientists has shown that cells from telomerase-deficient mice form tumors. Telomerase inhibition "may not be the phenomenal approach that we all hoped and prayed for," says Ronald A. DePinho of Albert Einstein College of Medicine in New York.

"It's a little confusing what the take-home message is," counters Jerry W. Shay of the University of Texas Southwestern Medical Center at Dallas. "The worst thing we can do is say that telomerase inhibition is dead on arrival."

DePinho and his colleagues, who describe their work in the Oct. 3 Cell, created telomerase-deficient mice by deactivating a gene that encodes an RNA sequence necessary for the enzyme's function. The scientists then bred the mice, producing five more generations lacking the enzyme.

With markers that label telomeres, the investigators found that this DNA grew shorter with each successive generation. Indeed, 5 percent of the chromosomes in cells from sixth-generation mice had no detectable telomeres.

As the telomeres shortened, more and more cells exhibited chromosomal instability, says DePinho. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed


An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.