Magazine article Clinical Psychiatry News

Tricyclics Are Associated with Metabolic Syndrome

Magazine article Clinical Psychiatry News

Tricyclics Are Associated with Metabolic Syndrome

Article excerpt

ISTANBUL, TURKEY -- The use of tricyclic antidepressants to treat depression and /or anxiety was associated with a sharply increased risk of metabolic syndrome, compared with other antidepressant classes in a large prospective Dutch cohort study.

The specific components of the metabolic syndrome exacerbated by tricyclic antidepressants (TCAs) were hypertension, abdominal obesity, and hypertriglyceridemia, Ari-anne K.B. van Reedt Dortland reported at the annual congress of the European College of Neuro-psychopharmacology.

The two clear take-home messages of this analysis from the Netherlands Study of Depression and Anxiety (NESDA) are: one, it's important to screen for these elements of the metabolic syndrome in patients who are being considered for TCA therapy or who are already on it; and two, when one or more of these elements is present, an alternative type of antidepressant is highly preferable in order to minimize the patient's risk of developing cardiovascular disease or diabetes, according to Ms. Reedt Dortland of Leiden (the Netherlands) University Medical Center.

NESDA is an ongoing 8-year prospective multicenter study involving 261 patients with current major depressive disorder only, 266 with a current pure anxiety disorder, and 690 with both, all diagnosed using DSM-IV criteria. …

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