Magazine article Clinical Psychiatry News

Relapses Seen after Stopping Antipsychotics

Magazine article Clinical Psychiatry News

Relapses Seen after Stopping Antipsychotics

Article excerpt

ISTANBUL, TURKEY -- Discontinuing maintenance antipsychotic therapy at the 2-year mark after a first episode of schizophrenia might not be in the best interest of most patients, a small prospective study suggests.

Treatment guidelines recommend continuing antipsychotic therapy for 12-24 months in patients who achieve symptom stabilization. But 26 of 33 patients (79%) enrolled in a prospective study of the effects of discontinuing maintenance therapy with flexible doses of injectable long-acting risperidone (Risperdal Consta) after 2 years relapsed within the next year, Dr. Robin Emsley reported at the annual congress of the European College of Neuropsychophar-macology

The study was sponsored by Janssen, maker of Risperidal Consta.

Median time to relapse after stopping maintenance therapy was 163 days. Eight patients relapsed within their first 6 months off the second-generation antipsychotic agent. And 8 of the 26 who relapsed required psychiatric hospitalization, according to Dr. Emsley of the University of Stellenbosch in South Africa.

When the study participants discontinued long-acting risperidone after 2 years of maintenance therapy, they were not permitted to use any antipsychotic agents, psychostimulants, or mood stabilizing drugs. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.