Magazine article Clinical Psychiatry News

Statins May Decrease Rate of Dementia by More Than 50%

Magazine article Clinical Psychiatry News

Statins May Decrease Rate of Dementia by More Than 50%

Article excerpt

VIENNA -- Statin treatment may reduce the risk of later dementia by more than 50%, a national Finnish study has determined.

"Disturbances in cholesterol metabolism have previously been linked to dementia development," Dr. Alina Solomon wrote in a poster presented at the International Conference on Alzheimer's Disease. However, she noted not all studies have concluded that statins confer a protective effect against dementia onset.

Dr. Solomon, of the University of Kuopio, Finland, and her colleagues examined this question using data from the national FINRISK study, a large, population-based survey of cardiovascular risk factors in Finnish citizens. The survey began in 1972 and is conducted every 5 years. The substudy of FINRISK included data on 17,257 citizens who were included in the 1997 and 2002 cohorts and who were at least 60 years old in 1995, when statins became available in Finland.

By the study's end at 2007, 1,551 subjects had developed dementia and 15,706 had not. Of those who developed dementia, 18% had taken at least 1 year of statin therapy, while 37% of those without dementia had taken a statin--a significant difference. …

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