Magazine article Clinical Psychiatry News

Prediabetes Is Tied to Accelerated Brain Aging, Even in Nondiabetics

Magazine article Clinical Psychiatry News

Prediabetes Is Tied to Accelerated Brain Aging, Even in Nondiabetics

Article excerpt

VIENNA -- Markers of metabolic dysfunction are associated with changes in brain volume and cognition, suggesting that these prediabetic conditions accelerate brain aging, according findings in a study of more than 2,000 subjects.

Subjects with these markers--hyperinsulinemia, hyperglycemia, and insulin resistance--had decreased total cerebral volume equivalent to 6 years' worth of structural brain aging, said Dr. Zaldy S. Tan at the International Conference on Alzheimer's Disease, which was sponsored by the Alzheimer's Association.

"These changes were seen even in nondiabetics," he said, hinting that metabolic dysregu-lation might affect the brain long before diabetes becomes clinically apparent.

Dr. Tan of Harvard Medical School, Boston, and his colleagues based the study on data extracted from the Framingham Heart Study Offspring Cohort. This group consists of 5,124 men and women who are the children of the original Framingham cohort. They have undergone up to eight examinations since their cohort was established in 1975; exams are conducted every 4-6 years. The researchers focused on 2,518 subjects who had attended the seventh examination cycle, were free of stroke and clinical dementia, and had undergone volumetric brain MRI and cognitive testing on the same day. Their mean age was 63 years; 269 had diabetes.

The researchers correlated MRI and cognitive measures to diabetes, fasting glucose levels, hemoglobin [A.sub.lc], fasting insulin, and homeostatic model assessment-estimated insulin resistance. …

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