Magazine article Science News

Cloning Method Yields Stem Cells: Reprogramming Technique Using Eggs Works in Humans

Magazine article Science News

Cloning Method Yields Stem Cells: Reprogramming Technique Using Eggs Works in Humans

Article excerpt

Cloning technology has been used to induce human eggs to reprogram adult cells into a primitive embryonic-like state. The accomplishment, reported in the Oct. 6 Nature, may one day help researchers develop a source of stem cells that could be used to replace a patient's own faulty cells.

Scientists had previously shown through cloning experiments that egg cells from many different kinds of animals could perform the feat, but until now there was no evidence that human eggs could do it.

"There was a big question mark whether this was indeed possible," says Dieter Egli, a researcher at the New York Stem Cell Foundation.

Though promising from a research perspective, the stem cells Egli and his colleagues produced can't be used to treat patients.

"This is only partial success," says George Q. Daley, a stem cell researcher at Children's Hospital Boston and Harvard Medical School, because the newly created stem cells contain three sets of chromosomes instead of the usual two.

The extra chromosomes come from the egg. In animal cloning, researchers remove the chromosome-containing nucleus from the egg and replace it with the nucleus from an adult cell. Something in the egg causes the adult cell to revert back to its earliest primordial stage so it acts like a fertilized egg and creates an embryo.

But when researchers tried that technique with human cells, it worked only when the adult cell nuclei were inserted into eggs that retained their own nuclei. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.