Magazine article Clinical Psychiatry News

Study Supports Criteria; Data Confusing

Magazine article Clinical Psychiatry News

Study Supports Criteria; Data Confusing

Article excerpt

The study by Dr. Stephanie J. Vos and her colleagues supports the emerging understanding of preclinical staging of Alzheimer's disease--a concept useful not only for identifying at-risk populations, but for stratifying patient groups in therapeutic trials, Dr. Ronald Petersen wrote in an accompanying editorial (Lancet Neurol. 2013 Sept. 4 [doi:10.1016/S1474-4422(13)70217-5]).

However, he noted, the authors' data on disease progression is "a bit more difficult to interpret than the frequencies of participants in each stage of preclinical AD."

For example, he noted, the researchers "chose to label the category for the next phase of progression in the AD spectrum as symptomatic AD rather than the more conventional mild cognitive impairment due to AD, amnestic MCI, or prodromal AD. The reason for this terminology is unclear and is likely to add to confusion in the published work."

Dr. Vos and her colleagues' dichotomization of subjects as normal or abnormal at baseline made no allowance for a symptomatic predementia, he noted--a position that "is inconsistent with the published work from other groups in the specialty. …

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