Magazine article Clinical Psychiatry News

Chronic Kidney Disease Linked to Increased Cancer Risk

Magazine article Clinical Psychiatry News

Chronic Kidney Disease Linked to Increased Cancer Risk

Article excerpt

AT SCM 14

LAS VEGAS -- Patients with chronic kidney disease appear to be at increased risk for cancer, a study showed.

A retrospective analysis of data on 31,896 participants in ALLHAT (the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) showed that during a mean 4.9 years of in-trial follow-up, 2,529 subjects were diagnosed with various cancers.

The 5-year rate of incident cancer was 7.24 cases per 100 person-years among subjects with a baseline normal estimated glomerular filtration rate (eGFR) greater than 90 mL/min per 1.73 [m.sup.2].

The cancer rate rose with decreasing renal function: 8.38 cases per 100 person-years in patients with a baseline eGFR of 60-89.9, 9.18 per 100 person-years in those with an eGFR of 45-59.9, and 11.58 per 100 person-years in patients with an eGFR below 45 mL/min per 1.73 [m.sup.2], Dr. Dhruti P. Chen reported at a meeting sponsored by the National Kidney Foundation.

An additional 4 years of follow-up for mortality because of cancer was available through national databases after ALLHAT ended. During the mean total 8.9 years of follow-up, there were 2,338 cancer-related deaths.

The 10-year rate of cancer mortality was 7.90 cases per 100 person-years in patients with an eGFR greater than 90; 7.71 person-years in those with an eGFR of 60-89.9; 10.11 per 100 person-years with an eGFR of 45-59.9; and 13.19 per 100 person-years in patients with an eGFR below 45 mL/min per 1.73 [m.sup.2], added Dr. …

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