Magazine article Clinical Psychiatry News

No Link Found between Antidepressants, Diabetes Risk

Magazine article Clinical Psychiatry News

No Link Found between Antidepressants, Diabetes Risk

Article excerpt

AT EASD 2014

VIENNA -- Long-term use of antidepressant medication does not appear to cause diabetes, according to findings from a longitudinal study.

The team, from the Institut National de la Sante et de la Recherche Medicale (INSERM) in Villejuif, France, found no association between fasting plasma glucose (FPG) or hemoglobin [A.sub.1c] levels measured over a 9-year study period and the use of antidepressants.

"Several studies have shown an association between antidepressant use and the risk of type 2 diabetes," reported Marine Azevedo Da Silva at the annual meeting of the European Association for the Study of Diabetes.

The reason for this remains unclear, so the hypothesis for the study was that "if antidepressant use is causally associated with type 2 diabetes, then it should also be associated with glucose dysregulation," said Ms. Azevedo Da Silva, a doctoral student at the Versailles (France) Saint-Quentin-en-Yvelines University.

While other research teams have examined this hypothesis, the results have been inconsistent, Ms. Azevedo Da Silva added. To solve some of the methodological issues of the prior studies, she and her colleagues used data from an epidemiological study on the insulin resistance syndrome (DESIR). This is a longitudinal cohort of 5,212 men and women without diabetes who were aged 30-60 years at recruitment.

Health assessments, including antidepressant use, FPG, and hemoglobin [A.sub.1c], were performed at four time points: at recruitment in 1994 to 1996, and then at 3-year intervals between 1997-1999, 2000-2002, and 2003-2005. Data on 4,869 participants who did not have diabetes at baseline were available for analysis. Diabetes was defined as an FPG of less than 7 mmol/L (126 mg/ dL) and no use of glucose-lowering medication. The majority (96%) of participants were not using antidepressants at baseline.

Baseline mean FPG and hemoglobin [A.sub.1c] levels were similar among antidepressant and non-antidepressant users, at 5.22 mmol/L (96 mg/ dL) and 5.22%, versus 5.32 mmol/L (96 mg/dL) and 5.35%, respectively. Among the 4% of subjects who used antidepressants, there was no difference in these blood glucose measures according to the type of antidepressant used. …

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