Magazine article Clinical Psychiatry News

Axis I Psychiatric Disorders May Be High in Skin-Restricted Lupus

Magazine article Clinical Psychiatry News

Axis I Psychiatric Disorders May Be High in Skin-Restricted Lupus

Article excerpt

The prevalence of psychiatric disorders is high among people with skin-restricted lupus, compared with the general population, yet most do not receive specialist mental health care or appropriate psychotropic treatment, researchers reported.

Investigators led by psychiatrist Isabelle Jalenques of the Clermont-Ferrand (France) University Hospital noted that psychiatric disorders had been extensively reported in patients with systemic lupus erythematosus (SLE), but no data existed on patients with skin-restricted disease (Br J Dermatol. 2016. doi: 10.1111/bjd.14392).

A previous exploratory study by the research group had shown that 60% of the 20 patients with subacute cutaneous lupus erythematosus and discoid lupus erythematosus studied had at least one psychiatric disorder. However, the study was limited by its size and lack of a control group.

In the current multicenter study, the researchers compared 75 outpatients with skin-restricted lupus (SRL) with 150 controls. The mean age of patients was 46 years, and the mean duration of disease was 10 years. The investigators discovered that almost 49% of the patients with SRL fulfilled criteria for at least one current Axis I psychiatric disorder, compared with 13% of controls (odds ratio, 5.0; P less than .001). Furthermore, 73% of patients fulfilled criteria for at least one lifetime Axis I psychiatric disorder, compared with 43% of controls (OR, 4.4; P less than .001).

The rates were close to those of patients with SLE for both current (42.2 and 46.7%) and lifetime psychiatric disorders (72%), the investigators noted. …

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