Magazine article Clinical Psychiatry News

Early MCI in Parkinson's Disease Tied to Greater Risk of Later Dementia

Magazine article Clinical Psychiatry News

Early MCI in Parkinson's Disease Tied to Greater Risk of Later Dementia

Article excerpt

DEVELOPING PERSISTENT MILD cognitive impairment soon after being diagnosed with Parkinson's disease significantly increased the risk of subsequent dementia, according to a cohort study that examined the natural history of mild cognitive impairment in 178 patients over 5 years.

After the researchers controlled for age, sex, and education, patients who had persistent mild cognitive impairment (MCI) by 1 year after their Parkinson's disease (PD) diagnosis had a 16.6-fold greater odds of subsequent dementia, compared with those who were cognitively normal (95% confidence interval, 5.1-54.7; P less than .001). Notably, early MCI significantly predicted dementia even if patients reverted to normal cognition with dopaminergic treatment, reported Kenn F. Pedersen, MD, PhD, of the Norwegian Centre for Movement Disorders at Stavanger University Hospital, and his associates. "Early PD-MCI, regardless of persistence or reversion to normal cognition, has prognostic value for predicting dementia in patients with PD," they concluded.

Their population-based study included white patients from Norway with a confirmed diagnosis of incident PD. Patients repeatedly underwent the Mini-Mental State Examination and a battery of tests of verbal memory, attention, executive functioning, and visuospatial skills (Neurology. …

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