Magazine article Clinical Psychiatry News

Extended-Release Adderall Improves ADHD over Entire Day with One Dose. (563 Children Studied)

Magazine article Clinical Psychiatry News

Extended-Release Adderall Improves ADHD over Entire Day with One Dose. (563 Children Studied)

Article excerpt

Adderall XR improves the symptoms of attention-deficit hyperactivity disorder in children throughout a school day and into the evening with one morning dose, reported Dr. Joseph Biederman of Massachusetts General Hospital, Boston, and his colleagues.

The response of children to Adderall XR improves with increasingly higher doses without significantly increasing the rate of most adverse events, the investigators said.

Teachers and parents rated the improvement of 563 children aged 6-12 years with attention-deficit hyperactivity disorder (ADHD) who were randomized to either Adderall XR or placebo.

The children in the Adderall XR group were split into those who received 10 mg/day for 3 weeks; 10 mg/day for 1 week and 20 mg/day for 2 weeks; and 10, 20, and 30 mg/day, increasing by 10 mg each week for 3 weeks. The study was funded by Shire Pharmaceutical Development Inc., manufacturer of Adderall XR.

At school, the Adderall XR group had an improvement in ADHD behavior that was roughly five times greater than in those who received placebo. Teachers assessed the students at 10 a.m. and 2 p.m. three times per week using the Conners Global Index Scale for Teachers (Pediatrics 110[2]:258-66, 2002). …

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