Magazine article Clinical Psychiatry News

Divalproex May Lower Impulsive Aggression. (Cluster B Diagnoses)

Magazine article Clinical Psychiatry News

Divalproex May Lower Impulsive Aggression. (Cluster B Diagnoses)

Article excerpt

BOCA RATON, FLA. -- Divalproex sodium appears to be effective in controlling impulsive aggression in patients with personality disorders, Dr. Alan Swann said in a poster presentation at a meeting of the New Clinical Drug Evaluation Unit sponsored by the National Institute of Mental Health.

Patients with cluster B diagnoses showed significant reductions in aggression, irritability, and verbal and physical assault in a randomized, controlled trial, said Dr. Swann of the University of Texas, Houston.

Clinical experience and earlier, smaller studies have suggested a role for divalproex in the treatment of behavioral symptoms such as irritability, impulsive aggression, and hostility in various psychiatric diagnoses. Such behaviors can be particularly problematic in patients with cluster B personality disorders, which include borderline, narcissistic, antisocial, and histrionic personality.

The current study involved 91 patients with cluster B diagnoses; scores of 15 or higher in the aggression scale of the Overt Aggression Scale-Modified (OASM-A) at two visits prior to randomization; and a history of physical or verbal outbursts, at least twice a week for the prior month, which caused marked distress or functional impairment. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.