Magazine article Clinical Psychiatry News

NSAID Use Linked to Lower Incidence of Alzheimer's. (29% Lower among Users)

Magazine article Clinical Psychiatry News

NSAID Use Linked to Lower Incidence of Alzheimer's. (29% Lower among Users)

Article excerpt

SAN FRANCISCO -- The use of NSAIDs or aspirin was associated with a reduced incidence of Alzheimer's disease in a large prospective study of elderly individuals in Cache County, Utah.

The largest reduction in risk was among former users of NSAIDs or aspirin who had taken the medications for 2 years or more. The incidence of Alzheimer's disease in that group was 29% of the rate seen in nonusers, Dr. John C.S. Breitner reported at the annual meeting of the American College of Clinical Pharmacology.

An earlier study in the same population included 5,092 people over the age of 65, representing 90% of the Cache County residents in that age group. These people were questioned closely about their use of NSAIDs, aspirin, non-NSAID pain relievers, [H.sub.2]-receptor blockers, and other stomach remedies.

The prevalence of Alzheimer's disease was reduced by about 50% among those who reported using aspirin or NSAIDs. Among individuals who reported taking both NSAIDs and aspirin, or two or more NSAIDs, the prevalence of Alzheimer's disease was 17% and 14% of that in nonusers. …

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