Magazine article Clinical Psychiatry News

Fibromyalgia's Musculoskeletal Pain May Ease with Pregabalin Therapy. (Effect Is Not on Mood)

Magazine article Clinical Psychiatry News

Fibromyalgia's Musculoskeletal Pain May Ease with Pregabalin Therapy. (Effect Is Not on Mood)

Article excerpt

NEW ORLEANS -- The widespread musculoskeletal pain experienced by patients with fibromyalgia improved following treatment with the investigational agent pregabalin, Dr. Leslie Crofford said.

In a multicenter, placebo-controlled trial that included 529 patients meeting the American College of Rheumatology criteria for fibromyalgia syndrome, those randomized to receive 450 mg of this drug showed significant improvement in mean pain scores, compared with those receiving placebo. They also were significantly more likely than those given placebo to have a 50% reduction in pain from baseline by 8 weeks (29% versus 13%), she said at the annual meeting of the American College of Rheumatology. Measures such as mean sleep quality, global impressions of change, and four domains of the SF-36 Health Survey also improved significantly.

"This agent seems to work on the symptom domains of pain, fatigue, and sleep, and gave patients a global improvement. It didn't have a significant effect on mood, providing further evidence that the symptoms of fibromyalgia are independent of mood to a certain extent," said Dr. …

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