Magazine article Drug Topics

New Immunomodulator Relieves Eczema

Magazine article Drug Topics

New Immunomodulator Relieves Eczema

Article excerpt


Atopic dermatitis, also known as eczema, is a chronic skin condition affecting more than 40 million Americans. Essentially, patients with eczema suffer from a disease of irritable skin.

Many eczema patients have high serum IgE levels, suggesting an allergic component. Consistent with this, there is a high correlation between eczema and other atopic diseases such as asthma and hayfever, but an exact immune cause has not yet been identified. Treatment of eczematous skin irritation has relied heavily upon the use of emollients to treat dry skin and on topical corticosteroids to alleviate patient discomfort during acute flare-ups.

One new option for treating eczema involves drugs that possess antiinflammatory properties but are not corticosteroids. Pimecrolimus (Elidel, Novartis) is a new topical immunomodulator recently approved for treating mild to moderate atopic dermatitis in patients as young as two years of age.

"We've had topical steroids to suppress the immune system for decades. Now, 40 years later, we have a drug in a new class of anti-inflammatories that doesn't lose efficacy over time and works fast. Without head-tohead studies, Elidel appears to be as efficacious as moderate-potency corticosteroids," said Ken Washenik, M.D., Ph.D., director of dermatopharmacology at New York University School of Medicine.

"The mechanism of Elidel is not fully understood," said Bob Cherill, research scientist and associate director of clinical development for Novartis Pharmaceuticals. "But it seems to affect T cells involved with inflammation. The active ingredient blocks T cell activation and prevents the release of inflammatory cytokines." Unlike corticosteroids, which suppress proliferation of a variety of cell types, pimecrolimus operates by a targeted mechanism acting only on T cells behaving aberrantly and may even be specific for skin T cells.

Washenik explained, "Elidel specifically suppresses inappropriately activated T cells, but it does not suppress the uninitiated immune system." This is a key feature since suppression of unstimulated immune cells could lead to widespread systemic immunosuppression, predisposing patients to infections and malignancies. Cherill added, "Elidel has no systemic side effects. It is a good anti-inflammatory for the skin, but its immunosuppressant activity is very low. Safety is its big advantage [over corticosteroids]."

In addition to its lack of systemic side effects compared with topically applied corticosteroids, pimecrolimus has the advantage of not causing skin atrophy That means with topical application of pimecrolimus, the skinthe body's first line of defense against the outside world-is not compromised. …

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