Magazine article Nutrition Health Review

Genetic Mutations May Lead to Colon Cancer

Magazine article Nutrition Health Review

Genetic Mutations May Lead to Colon Cancer

Article excerpt

Researchers claim that at least 70 genetic mutations are involved in the formation of colon cancer, far more than scientists had thought. Based on the study, researchers are suggesting a new approach to colon cancer treatments targeting multiple genes and pathways simultaneously.

Current cancer treatments target just one or two known cancer-driver genes believing this would be beneficial to patients. Although the tumor burden might be reduced temporarily, tumor growth usually resumes. The findings contradict the earlier idea that only a few mutated genes are important in the development of cancerous tumors.

"The way we've been treating patients up to now is to just go after one target when we should be going after three to four different pathways simultaneously," said Dr. Jerry W. Shay, Vice Chairman and Professor of Cell Biology at the University of Texas.

Under the old model, scientists believed there were 1 5 1 candidate genes and that mutations in just eight to 15 of them would lead to cancer. …

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