Magazine article Drug Topics

Researchers Explore Drug Combinations That Reduce Adverse Effects

Magazine article Drug Topics

Researchers Explore Drug Combinations That Reduce Adverse Effects

Article excerpt

esearchers using data from the FDA's Adverse Event Reporting . System (FAERS) have hypothesized that certain drug combinations can be used to mitigate serious adverse events. They have tested their hypothesis with an animal model to determine the mechanisms of action by which these drugs interact. According to a study published in October in the journal Science Translational Medicine, this could be the starting point for the development of clinical trials to investigate safer combinations of drugs.

/Lead author JT- Ravi Iyengar, PhD, professor in the Department of Pharmacology and Systems Therapeutics, and director of the Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, explained that after studying different drug combinations in FAERS, the researchers noticed that the first drug showed different levels of adversity when combined with different second drugs.

Rosiglitazone plus exenatide

One combination that stood out was that of rosiglitazone and exenatide, used to treat type 2 diabetes. Patients who were prescribed both rosiglitazone and exenatide had a low rate of myocardial infarction (MI), 2%, compared to other second drugs used in combination with rosiglitazone: Rosiglitazone and metformin had a 21% rate of MI; rosiglitazone and aspirin had a 17% rate of MI; and rosiglitazone and warfarin had a 13% rate of MI.

"As biologists, we were trying to figure out the molecular mechanisms in which these drugs interact," Iyengar said. "The rosiglitazone and exenatide combination was easy to work on, because it was a mouse model of diabetes using spontaneously diabetic mice."

The researchers decided to study the clotting mechanism because rosiglitazone has been associated with increased risk of MI and stroke in patients with type 2 diabetes. Because of the drug's cardiovascular effects, its use was restricted in this population in the United States in 2010. …

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