Magazine article Drug Topics

Outcome Study Shows Benefits of Surfactants

Magazine article Drug Topics

Outcome Study Shows Benefits of Surfactants

Article excerpt

In very-low birthweight infants, treatment with surfactant has improved survival, decreased morbidity, reduced the use of hospital resources, and resulted in substantial cost savings, according to researchers at the National Perinatal Information Center (NPIC) in Providence, R.I.

The epidemiologic outcome study, supported by a grant from the National Heart, Lung, & Blood Institute, reviewed data from 5,629 newborn infants in 14 hospitals. All infants weighed between 500 gm and 1,500 gm and were born between 1985 and 1990. Clinical and financial data were compared in two groups of high-risk infants: Those born before the use of surfactant became common clinical practice in their hospital were in one group, and the other was made up of high-risk infants born after surfactant became standard practice. This retrospective study determined that availability of surfactant resulted in:

* A 30% reduction in the odds of death in very low birthweight infants.

* A 40% decrease in mortality in newborns with bronchopulmonary dysplasia. …

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