Magazine article Drug Topics

FDA Updates Chantix Label: Possible Alcohol Interaction

Magazine article Drug Topics

FDA Updates Chantix Label: Possible Alcohol Interaction

Article excerpt

MEDICATION SAFETY

FDA has warned that the smoking-cessation drug varenicline (Chantix; Pfizer) can interact with alcohol, causing some patients to experience an increase in alcohol-related intoxicating effects that are sometimes associated with aggressive behavior and/or amnesia. In addition, rare accounts of seizures in patients treated with Chantix have been reported.

Until patients know how Chantix affects their ability to tolerate alcohol, they should decrease the amount of alcohol they drink. Patients who have a seizure while taking Chantix should stop the medicine and seek medical attention immediately.

Label changes

FDA has approved changes to the Chantix label to warn about these risks. A detailed data summary is included in FDA's Drug Safety Communication (http://bit.ly/varenkline).

In September 2014, FDA approved updated label changes for Chantix that included data from a meta-analysis of five clinical trials that showed no increased risk in the incidence of suicidal ideation and/or behavior in patients taking Chantix vs. a placebo. …

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