Magazine article Drug Topics

Hospital Notes

Magazine article Drug Topics

Hospital Notes

Article excerpt

First-line strategy

The growing problem of bacterial resistance to traditional antibiotics has prompted several experts to suggest that new antibiotics, such as moxifloxacin and gatifloxacin, should be used more often as first line treatment for respiratory tract infections. This approach differs from the current practice of using older classes of antibiotics first and administering the newer antimicrobial agents, such as fluoroquinolones, only if older ones like the macrolides (when used as first-line therapy) are not effective.

The recommendation was made during a symposium sponsored by the Postgraduate Institute of Medicine (PIM). It was held during the annual meeting of the American College of Physicians in April. "When deciding on a treatment regimen for patients, the most prevalent pathogens as well as current resistance patterns must be considered, ' said Jeanne K: Cornish, R.Ph., director of education at P1M. "For example, resistance to commonly used agents in community-acquired pneumonia [CAP], such as penicillin and trimethoprim/sulfamethoxazole, is rising, requiring a consideration of new therapeutic options. …

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