Magazine article Drug Topics

Cheeky New Drug Delivery System in Development

Magazine article Drug Topics

Cheeky New Drug Delivery System in Development

Article excerpt

A new concept for taking drugs by mouth is more than just tongue-in-cheek. This new drug delivery system consists of a mucoadhesive patch that can be stuck to the inside of a patient's cheek. The product is under development at Dow Corning Corp., Midland, Mich., in conjunction with the department of pharmaceutics at the University of Illinois-Chicago.

The cheek patch is able to deliver certain drugs--through the inner cheek skin, or buccal mucosa--that normal skin patches can't deliver, explained Padmanabh Bhatt, a research specialist and group leader of pharmaceutical development at Dow Corning, who has been involved with the product's development. Therapeutically used peptides and proteins can be delivered better by transbuccal system than by a skin patch, he said.

Skin is keratinized; its protective, tough surface prevents many kinds of drugs from being absorbed into the body. But the nonkeratinized tissue inside the mouth allows certain drugs to be absorbed that cannot be absorbed from a skin patch, Bhatt explained.

The advantage of using a patch of one sort or another is that it can deliver a steady supply of certain medications for a longer period of time than is possible if the drugs are swallowed or injected, he continued. …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.