Magazine article Drug Topics

Antidepressants Linked to Sexual Dysfunction

Magazine article Drug Topics

Antidepressants Linked to Sexual Dysfunction

Article excerpt

For some patients with clinical depression, sexual dysfunction is a symptom of their illness. For others, it's a frustrating side effect of their medication.

Authors of a study published last December in the Journal of Clinical Psychiatry concluded that "bupropion may be an appropriate antidepressant for patients who develop sexual dysfunction while taking fluoxetine or in patients in whom sexual dysfunction is a concern."

In his private practice, Elmer Gardner, M.D., a psychiatrist from Washington, D.C., observed a high incidence of sexual dysfunction in patients taking fluoxetine, but he hadn't seen much sexual dysfunction with bupropion. Based on his personal experience, he suggested that Burroughs Wellcome conduct a study to determine the effect of bupropion on sexual dysfunction.

The study, which involved both male and female outpatients who had sexual dysfunction while taking fluoxetine (Prozac, Eli Lilly & Co.), assessed the effect of bupropion (Wellbutrin, Burroughs Wellcome Co.) on orgasm function, libido, and satisfaction with overall sexual functioning.

After a two-week washout period, 39 patients who had previously been taking fluoxetine and experienced an orgasm or delayed orgasm were switched to bupropion and treated for eight weeks.

Of the 15 males and 16 females who completed the study, complete resolution of orgasm dysfunction was reported in 26 patients (84%), and partial resolution of orgasm dysfunction was reported in three patients (10%). …

Search by... Author
Show... All Results Primary Sources Peer-reviewed

Oops!

An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.