Magazine article Drug Topics

RU-486 to Enter U.S. Soon for Multiple-Use Experiments

Magazine article Drug Topics

RU-486 to Enter U.S. Soon for Multiple-Use Experiments

Article excerpt

Roussel-Uclaf's progesterone receptor antagonist, mifepristone--better known as RU-486--could be legally imported into this country within the next month. It all depends on finalization of contract negotiations between the French drug manufacturer and the Population Council, a New York City-based research group.

The use of mifepristone here has been a subject of much controversy. As the start of clinical trials for "the French abortion pill" draws near, right-to-life advocates are letting their opinions be known. Oregon Health Sciences University in Portland, a potential clinical study site, has been picketed by Pro-Life interest groups and has received several hundred letters protesting the use of the drug, according to Lee Lewis-Husk, a spokeswoman for the university.

Along with the statements of opposition, the university has received many letters applauding its intended research, she told Drug Topics. The university plans to study mifepristone not only as an abortifacient but also for its potential as a long-acting contraceptive implant and for the treatment of hormone-dependent tumors, Lewis-Husk said.

Indeed, reports in the literature suggest that mifepristone may have several potential therapeutic benefits. …

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