Magazine article Drug Topics

Drug-Resistant TB Is Often Traced to Noncompliance

Magazine article Drug Topics

Drug-Resistant TB Is Often Traced to Noncompliance

Article excerpt

Nearly 10% of patients with tuberculosis are resistant to standard treatment with isoniazid and rifampin, according to a report in the Journal of the American Medical Association. In an epidemiological study of 4,874 cases of TB, researchers at the Division of Tuberculosis Elimination at the Centers for Disease Control & Prevention (CDC) in Atlanta uncovered the following disturbing statistics about the emergence of multidrug-resistant TB in the United States:

* Of all cases surveyed, 14% were resistant to one or more TB drugs.

The resistance rate was 13.4% for new cases and 26.6% for cases with recurrent disease.

* Of the cases showing drug resistance, 58.5% were resistant to one drug; 23.5% were resistant to two drugs; 7.8% were resistant to four drugs; 4% were resistant to five or more drugs.

Of all cases of multidrug-resistant TB, 60% occurred in New York City

According to the authors, "the study supports the use of four drug regimens, especially in areas with drug-resistant TB. …

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