Magazine article Drug Topics

Early Sightings

Magazine article Drug Topics

Early Sightings

Article excerpt

Parkinson's: Mistaken cases

It appears that metoclopramideinduced extrapyramidal symptoms in elderly patients are often mistaken for Parkinson's disease, according to a recently published article in the Journal of the American Medical Association (JAMA.1995;274: 1780-1782).

A review of New Jersey Medicaid prescription claims data from enrollees aged 65 years and older determined that patients who use metoclopramide were three times more likely to fill a prescription for a levodopa-containing medication, compared with patients who don't take metoclopramide.

The investigators also found that the risk of being prescribed an antiParkinson's agent increased with increasing metoclopramide dose.

"Considerable clinical benefit in the care of the elderly could result if clinicians had a higher degree of suspicion for drug-induced extrapyramidal dysfunction in the treatment of the geriatric patients with Parkinsonian symptoms and if they adjusted the potentially offending agent before adding a new drug that may be both toxic and minimally effective for this purpose," the authors stated.

Erythropoietin efficacy Researchers from the State University of New York Health Science Center, Brooklyn, N.Y. …

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