Newspaper article THE JOURNAL RECORD

Oklahoma Medical Research Foundation Scientists Report Finding on Cancer-Related Genes

Newspaper article THE JOURNAL RECORD

Oklahoma Medical Research Foundation Scientists Report Finding on Cancer-Related Genes

Article excerpt

Research by Oklahoma Medical Research Foundation scientists resulted in a new discovery about the role two genes play in the development of certain types of cancer.

The findings offer clues about the causes of breast cancer and certain types of leukemia and how they may be stopped. The research appears in the latest issues of two scientific journals - Molecular and Cellular Biology and the Public Library of Science One.

For years, scientists have known that a certain gene - known as Notch - is essential for the production of many types of cells in the body for the proper function of various organs. But research has found that when this gene is "turned up," a process that can occur naturally and will amplify the gene's effects, it can lead to the development of cancers such as breast cancer and T-cell leukemia.

For more than 20 years, OMRF's Xiao-Hong Sun has studied the formation of the immune system and leukemia. In two new studies, a research team led by Sun now has shown how the Notch gene plays a critical role in the production of normal immune cells and how excessive Notch causes T-cell leukemia.

When Sun's team turned up the Notch gene in laboratory mice, the animals experienced rapid tumor growth and died within two months. …

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