Newspaper article THE JOURNAL RECORD

OMRF Scientist Reverses Cell Division: Discovery May Help in Cancer Treatment

Newspaper article THE JOURNAL RECORD

OMRF Scientist Reverses Cell Division: Discovery May Help in Cancer Treatment

Article excerpt

A scientist with the Oklahoma Medical Research Foundation has found a way to reverse the process of cell division, OMRF officials said Wednesday.

The discovery could have important implications for the treatment of cancer, birth defects and numerous other diseases and disorders. The findings of Gary J. Gorbsky, Ph.D., appear in the April 13 issue of the journal Nature, one of the world's leading scientific publications.

No one has gotten the cell cycle to go backwards before now, said Gorbsky, who holds the W.H. and Betty Phelps Chair in Developmental Biology at OMRF. This shows that certain events in the cell cycle that have long been assumed irreversible may, in fact, be reversible.

Cell division occurs millions of times each day in the human body and is essential to life itself. In the lab, Gorbsky and his OMRF colleagues were able to control the protein responsible for the division process, interrupt and reverse the event, sending duplicate chromosomes back to the center of the original cell, an event once thought impossible.

Our studies indicate that the factors pointing cells toward division can be turned and even reversed, Gorbsky said. If we wait too long, however, it doesn't work, so we know that there are multiple regulators in the cell division cycle. Now we will begin to study the triggers that set these events in motion. …

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