Newspaper article International New York Times

Injection to Thwart H.I.V. Shows Promise ; Monthly Shots Provide Protection against AIDS in Monkeys, Studies Find

Newspaper article International New York Times

Injection to Thwart H.I.V. Shows Promise ; Monthly Shots Provide Protection against AIDS in Monkeys, Studies Find

Article excerpt

Versions of already approved drugs kept monkeys infection-free for weeks, and researchers hope that a dose every three months could work in humans.

Researchers are reporting that injections of long-lasting AIDS drugs protected monkeys for weeks against infection, a finding that could lead to a major breakthrough in preventing the disease in humans.

Two studies by different laboratory groups each found 100 percent protection in monkeys that got monthly injections of antiretroviral drugs, and there was evidence that a single shot every three months might work just as well.

If the findings can be replicated in humans, they have the potential to overcome a major problem in AIDS prevention: that many people fail to take their antiretroviral pills regularly.

A preliminary human trial is to start late this year, said Dr. Wafaa El-Sadr, an AIDS expert at the Mailman School of Public Health at Columbia University, but a larger trial that could lead to a treatment in humans may still be some years away.

It has been known since 2010 that healthy people taking a small daily dose of antiretroviral drugs -- a procedure known as pre- exposure prophylaxis, or PreP (pronounced prep) -- can achieve better than 90 percent protection against infection.

But in several clinical trials since then in gay men, in intravenous drug users and in couples where one partner is infected, it has been shown that the only participants protected were those who took their pills every day without fail. Many did not.

The failure rate was particularly acute among women in Africa. Although some participants in one PreP study told researchers that they were scared by rumors about side effects, many also said they were afraid to keep the pills in their home because their sexual partner or a neighbor might see them and mistakenly assume they already had the disease. …

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