Newspaper article The Topeka Capital-Journal

Drug Combination May Help If Statin Doesn't Work Alone

Newspaper article The Topeka Capital-Journal

Drug Combination May Help If Statin Doesn't Work Alone

Article excerpt

Dear Doctor K: Despite taking statins, my cholesterol hasn't dropped as low as my doctor would like. I figured he'd put me on the new PCSK9 inhibitors. Instead, he suggested that I stay on my statin, but also take another drug called ezetimibe. What can you tell me about this combination?

Dear Reader: From what you say, I assume your doctor has used the highest dose of the most potent statins before giving up on those drugs. There are very few people whose cholesterol does not drop substantially on statins alone.

However, if your cholesterol still is not low enough despite maximizing statin treatment, then you do need something else. The cholesterol-lowering drugs known as PCSK9 inhibitors roared onto the market last year. Thanks to their impressive performance in clinical trials -- in one year, they lowered LDL ("bad") cholesterol levels by 40 to 60 percent -- doctors and patients alike greeted them with excitement. …

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