Type 2 Diabetes in Childhood and Adolescence: A Global Perspective

By Martin Silink; Kaichi Kida et al. | Go to book overview

chapter 10

Long-term outcome of type 2 diabetes in adolescence

Yasuko Uchigata


Introduction

Type 2 diabetes mellitus has been reported in children in Japan, the United States, Pacific Islands, Hong Kong, Australia, and the United Kingdom. 1-6 Kitagawa et al.2 reported that type 2 diabetes was more common than type 1 diabetes in Japan, accounting for 80% of childhood diabetes. The incidence almost doubled between 1976-80 and 1991-95. 2 The proportion of patients with early onset type 2 diabetes registered with the Diabetes Center, Tokyo Women's Medical University (TWMU) increased by 50% between 1960-1975 and 1986-1995 (TWMU database for 1960-1995). 7

Thus, there is evidence that the incidence of type 2 diabetes mellitus is higher in young Japanese than in young Caucasians. 1,8 Since we first reported the young age of onset of many Japanese with type 2 diabetes attending our Diabetes Center in 1990, 1 it has become obvious that many develop severe diabetic vascular complications in their thirties 9 and show a higher incidence of diabetic nephropathy than that in Pima Indians with type 2 diabetes or Caucasian type 1 diabetes patients of comparable age. 10 Our findings on long-term diabetic complications of type 2 diabetes are felt to be representative of Japanese patients. Data on complications in other Asian and non-Asian populations with adolescent-onset type 2 diabetes are not available. In this chapter we describe

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