Besides genetic predisposition, obesity is considered as the most important risk factor for type 2 diabetes. 1,2 The strong relationship between the risk of type 2 diabetes, on the one hand, and body mass index (BMI) or weight gain, on the other hand, has been demonstrated in several studies including both men and women. 3,4 Besides the degree of obesity per se, several other factors obviously play a crucial role such as the abdominal distribution of adiposity 5,6 and the duration of overweight. 7,8 Conversely, numerous studies have demonstrated that, among obese subjects, successful weight loss results in a reduction in both the incidence and the severity of type 2 diabetes, whatever the therapeutic mean used (review in references 9 and 10).
Everybody agrees upon the fact that lifestyle modification is the cornerstone of the treatment of obese subjects with type 2 diabetes. 10 Initial recommendations to any obese diabetic patient should thus include optimization of the meal plan and enhancement of physical activity. In case of failure of conservative treatment, which unfortunately is very common, pharmacological approaches should be considered, targeting