The Biology of Aging: Observations and Principles

By Robert Arking | Go to book overview

Index
accelerated aging, mice, 376
actuarial analysis
creatinine clearance, 56–58
cross-sectional studies, 54–55
empirical longitudinal and cross-sectional comparisons, 56–62
growth curves of adolescents, 60, 61
longitudinal studies, 55–56
maximum oxygen uptake, 58–60, 61
weight, 56–57
adolescents, growth curves, 60, 61
age
chronological changes, 56
relationship to mortality, 35
U.S. population by, 40
aged animals, as survivors, 20
age-dependent changes, architecture, 355–357
age-related changes. See also actuarial analysis;
age-specific mortality. See also mortality
definition, 41
Drosophila, 270, 275
in Sweden, 509
in United States, 42
age structure
changes during 20th century, 507–510
developed and less developed countries, 508
aging. See also cellular aging; human aging; human aging, modulation; stochastic theories
accelerating or retarding changes, 69–71
avian, 129–130
bacterial, 107–110
biological traits, 10, 14–15, 505
definitions, 9–13
deteriorative changes with time, 10
determinants, 494
environmental changes modulating, 68–69
evidence, 6–8
fungi and mitochondria in senescence, 118– 119
immunosenescence and, 466–470
inflammatory parameters, 471
insect, 123–126
invertebrate, 119–131
mammalian, 126–129, 296
models, 13
modular nature of organisms, 131
physiological variables, 75
plant, 130
plasticity, 21–23
postmaturational changes, 71–72
protistan, 96–97, 107–116
rates, 17, 72–90
relationship to disease, 62–63, 137–139, 198–201
rotifer, 119–121
sources of information, 24–25
study of, 4, 5–9, 11, 51–52, 104
Tetrahymena, 112
theories of, 24, 105–107, 357–358
vertebrate, 126–130
Volvox, 116–118
yeast, 112–116
aging syndromes
Down's syndrome, 333–334
Hutchinson–Guilford syndrome, 334
progeria, 334
Werner's syndrome, 334–335
algae, somatic and reproductive cells, 116–118
alpha-tocopherol, 384. See also vitamin E
altered protein theory, 361, 366–367
Alzheimer's disease
abnormal apoptosis, 447
age-related pathology, 180–184
amyloid angiopathy, 182
genetic mutations, 183
inflammation, 183–184, 471–472
natural history, 181
risk factors, 180–181
American Association for Advancement of Science, website on aging, 24
amoebae. See also protests
aging process, 110–111
amphibians, maximum life spans, 127

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