It's not Just Growing Pains: A Guide to Childhood Muscle, Bone, and Joint Pain, Rheumatic Diseases, and the Latest Treatments

By Thomas J. A. Lehman | Go to book overview

Glossary

amyloidosis: A rare condition of abnormal protein deposition that may damage the kidneys or other organs. Although often described in the old literature, it rarely affects children with arthritis in the modern era

aortitis: Inflammation of the aorta. The aorta is the main blood vessel carrying blood out from the heart to the rest of the body. Although it can be inflamed in many places, most often it is inflamed right at the junction with the heart. This produces inflammation of the valves, which may leak as a result.

arthralgia: Pain around the joint without swelling, redness, or limitation of motion as required for the definition of arthritis.

arthritis: Pain, swelling, redness, or limitation of a joint (any two). There are two types of arthritis. Osteoarthritis is a mechanical problem that results from injury or gradual wear and tear. Inflammatory arthritis is the result of an abnormal response by the tissues that make up the joint, as if there was an infection present. Most cases of inflammatory arthritis in childhood are “idiopathic,” meaning we do not know its cause. This is the most common type of arthritis in children.

biologies: Injectable medications that include in their makeup either antibodies directed against human molecules or receptors for human molecules. These antibodies or receptors are usually produced by living cells in culture.

bisphosphonates: A group of drugs that serve to prevent the removal of calcium from the bones. The result over time is that patients with osteoporosis who are treated with bisphosphonates have fewer fractures than those who are not treated. However, the drugs are not safe in pregnancy and are cleared only slowly from the body. Thus, the safety of their use in someone who might become pregnant is uncertain.

bone sean: A specialized test using a radioactive tracer that is taken up by bone cells. Since irritated bone cells are more active, increased accumulation of the tracer is characteristic of infections, fractures, and arthritis or bone tumors (see Chapter 24).

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