Saint-Lô (săN-lō), town (1990 pop. 22,819), capital of Manche dept., NW France, in Normandy. It is an agricultural center and has famous horse stables. Wood products, plaster, and clothing are manufactured. An old Gallo-Roman town, Saint-Lô was a medieval fortress and was the scene of a massacre of Huguenots in the 16th cent. Saint-Lô has been rebuilt since its virtual destruction during the Allied invasion of Normandy in 1944.