progesterone (prōjĕs´tərōn´), female sex hormone that induces secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. A steroid, progesterone is secreted chiefly by the corpus luteum, a group of cells formed in the ovary after the follicle ruptures during the release of the egg cell. If fertilization does not take place, the secretion of progesterone decreases and menstruation occurs. If fertilization does occur, progesterone is secreted during pregnancy by the placenta and acts to prevent spontaneous abortion; the hormone also prepares the mammary glands for milk production. Progesterone is also synthesized from cholesterol in the cortex of the adrenal gland where it is a precursor for the synthesis of other steroids including testosterone. Synthetic compounds with progesteronelike activity have been developed that, along with estrogen, are used in oral contraceptives.