Male Infertility Could Signal Other Genetic Problems

By Johnson, Kate | Clinical Psychiatry News, January 2004 | Go to article overview

Male Infertility Could Signal Other Genetic Problems


Johnson, Kate, Clinical Psychiatry News


SAN ANTONIO -- Extremely low sperm counts are often caused by genetic defects that could pose other health risks to affected men and their potential offspring, Dolores Lamb, Ph.D., said at the annual meeting of the American Society for Reproductive Medicine.

"Normally in evolution, from a genetic standpoint, infertility is the end of the line. Nature has a built-in mechanism against passing along serious genetic defects to the next generation," explained Dr. Lamb, professor of urology and molecular and cellular biology at Baylor College of Medicine, Houston.

However, techniques that enable defective sperm to fertilize an egg--testicular sperm extraction and intracytoplasmic sperm injection (ICSI)--have made it possible for men to bypass that protective mechanism and father children, she said.

"Couples need to understand our level of ignorance. Because we don't understand all the genetic reasons behind male infertility, they need to know there may be other consequences beyond simply being infertile. Even with all the tests we can perform, there is no guarantee of a perfect baby," Dr. Lamb said in an interview.

Most studies suggest that there is no increased rate of birth defects among children conceived through ICSI, and chromosome problems in this population seem to be primarily restricted to the predicted sex chromosome abnormalities linked to male infertility. Still, some experts fear there may be undiscovered problems in children born from the sperm of severely azoospermic men.

"With chromosomal tests, it's like you are only looking at the outside of the 'Encyclopaedia Britannica.' You can say, 'Yes, we have an extra volume,' or 'We're missing a volume,' but you can't see if you're missing a chapter, which would be like missing a gene, or if you're missing a word, which would be like missing a portion of a gene. These microdeletions could potentially totally change or abolish the function of that protein." Dr. Lamb explained at the meeting.

She and her colleagues recently uncovered deficiencies in mismatch repair genes in some men with testicular failure, predominantly those with Sertoli-cell-only syndrome (Mol. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Male Infertility Could Signal Other Genetic Problems
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Author Advanced search

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.