Remission Rate of 66% Seen after 12 Weeks of Fluoxetine

By Brunk, Doug | Clinical Psychiatry News, February 2007 | Go to article overview

Remission Rate of 66% Seen after 12 Weeks of Fluoxetine


Brunk, Doug, Clinical Psychiatry News


SAN DIEGO -- More than two-thirds of children and adolescents with major depressive disorder who were treated with fluoxetine were in remission by week 12 of treatment, yet almost half of remitters had at least one residual symptom by week 12.

The findings are important because "knowing how early clinicians may expect response or remission in their patients is clinically valuable," Dr. Rongrong Tao said at the annual meeting of the American Academy of Child and Adolescent Psychiatry.

"It may improve [drug] adherence. Knowing the time course of depressive symptom improvement may be helpful in guiding" treatment decisions, Dr. Tao said.

In an open-label study funded by the National Institute of Mental Health, Dr. Tao and her associates in the department of psychiatry at the University of Texas Southwestern Medical Center at Dallas enrolled 168 outpatients aged 7-18 years who had a diagnosis of nonpsychotic major depressive disorder.

Patients with a diagnosis of bipolar I or II disorder were excluded from the study, as were those with anorexia nervosa or bulimia and those with a history of alcohol or substance abuse dependence within 6 months of study entry.

Between 1999 and 2005, the patients received 12 weeks of fluoxetine, starting with a dosage of 10 mg/day for week 1 and increased to 20 mg/day for week 2. …

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