Sperm Cells Created from Bone Marrow

The Birmingham Post (England), April 13, 2007 | Go to article overview

Sperm Cells Created from Bone Marrow


Byline: By Alex Young

Immature sperm cells have been created from human bone marrow, it was revealed today.

The breakthrough raises the future possibility of manufacturing sperm that can be used in IVF treatment or to restore fertility to men made sterile by cancer therapy.

Such applications are still many years away. But scientists hope to grow fully formed sperm cells in as little as three years.

At the same time they fear that new legislation may bring the work to a halt.

The Government's recent fertility White Paper proposes a ban on using artificially created sperm or eggs in assisted reproduction.

The research, conducted in Germany, is published today in the journal Reproduction: Gamete Biology.

A team led by Prof Karim Nayernia, from the University of Gottingen, first took bone marrow from male volunteers. From the samples, they isolated mesenchymal stem cells, which have previously been shown to grow into body tissues such as muscle.

Stem cells are immature cells that can be made to follow different functional pathways.

Using a form of vitamin A, the scientists coaxed the mesenchymal cells to become primordial germ cells (PGCs) - the first stage in the genesis of sperm.

Specific genetic markers showed that some PGCs had further developed into more advanced spermatagonial stem cells.

Under normal circumstances, these cells eventually turn into mature, func-tional sperm that can fertilise an egg.

About three per cent of the original bone marrow stem cells were able to reach the point of being spermatagonial cells.

In earlier work Prof Nayernia derived sperm stem cells from mouse bone marrow and transplanted them into the animals' testes. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Sperm Cells Created from Bone Marrow
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.