Type 1 Diabetes Patients Face Lower Schizophrenia Risk

By Gardner, Jonathan | Clinical Psychiatry News, March 2008 | Go to article overview

Type 1 Diabetes Patients Face Lower Schizophrenia Risk


Gardner, Jonathan, Clinical Psychiatry News


Patients with type 1 diabetes are at a significantly reduced risk of developing schizophrenia and related disorders, suggesting a need to study the genetic traits and environmental triggers that can lead to either condition, Finnish investigators have reported.

The incidence of schizophrenia, including schizoaffective disorder, schizophreniform disorder, and schizotypal personality disorder, was 0.21 per 10,000 person-years in those with type 1 diabetes and 0.56 per 10,000 person-years in those without the disease, the cohort study showed. The relative risk of a person with type 1 diabetes having schizophrenia was decreased by 62% (relative risk 0.38), compared with a person without type 1 diabetes.

Researchers drew on data from nationwide patient registers for type 1 diabetes and schizophrenia. A total of 5,009 people with type 1 diabetes and 10,931 with schizophrenia were born in Finland from 1950 to 1959. These patients were followed from 1969 through 1991, the investigators wrote.

In a register-based sample, 906 individuals in a separate study of schizophrenia were diagnosed by a procedure in which psychiatrists made DSM-IV diagnoses based on case-note information and consensus. When this method was used, 24 patients had a confirmed diagnosis of both diseases. …

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