Web Program Connects Players in AD Trials
Sullivan, Michele G., Clinical Psychiatry News
An interactive telephone- and Web-based service now lets Alzheimer's patients, caregivers, and their physicians connect more easily with ongoing clinical trials.
The service - Alzheimer's Association TrialMatch - has the potential to greatly enrich the research into more effective treatment options and the ultimate goal of an Alzheimer's cure, William Thies, Ph.D., chief medical officer of the Alzheimer's Association, said at a press briefing.
"Alzheimer's disease is clearly the No. 1 health challenge of the 21st century, and research is the only way to solve this problem," Dr. Thies said at the meeting in Honolulu. "If patients are not enrolling in trials, there can be no advances in diagnosis, treatment, and prevention, making the lack of study participants a significant health issue. TrialMatch provides a first-of-its-kind service in Alzheimer's by delivering a user-friendly and individualized guide to clinical trials for people with Alzheimer's, their health care professionals, caregivers, and healthy volunteers."
There are about 150 clinical studies for Alzheimer's and dementia ongoing. Unfortunately, not enough patients volunteer for them - a problem that slows recruiting and drags out the overall length of the trial, Dr. Reisa Sperling said in an interview.
"At the rate we have people signing up now, it takes 12-18 months just to complete enrollment for a study," said Dr. Sperling, director of clinical research at the Memory Disorders Unit, Brigham and Women's Hospital, Boston. "Since each one of these trials lasts for 18-24 months, that means each one takes 3-4 years to get an answer. This is not doable with the current scale of research." Currently, there are 10 drugs in large-scale clinical trials and another 20 in preclinical studies.
Even when patients do volunteer for trials, screening eliminates many possible candidates, she said. "For every patient we enroll, we typically need to screen three or four. TrialMatch will collect detailed information in a confidential way, online, and that will speed up the matching process considerably."
Interested parties visit the TrialMatch Web site (www.alz.org/TrialMatch) and identify themselves as a patient, caregiver, physician, researcher, or health volunteer. The program then creates a user name, password, and a personal profile that matches the user to trials for which he may qualify.
At any time in the process, users can also call a toll-free number (800-272-3900) to speak with a volunteer who will walk them through the process. Specialists who are available 24 hours a day help to match individuals to clinical trials for which they are eligible, based on study inclusion/exclusion criteria, diagnosis, treatment history, and location. …