Gene Discovery Brings Hope on Alzheimer's; CARDIFF SCIENTISTS FIND CAUSE OF INCREASED RISK OF DISEASE

Western Mail (Cardiff, Wales), April 4, 2011 | Go to article overview

Gene Discovery Brings Hope on Alzheimer's; CARDIFF SCIENTISTS FIND CAUSE OF INCREASED RISK OF DISEASE


Byline: HELEN TURNER

FAMILIES with relations suffering from Alzheimer's disease have been offered hope by a breakthrough at a Welsh university.

A leading scientist at Cardiff University has identified five genes that increase the risk of developing the disease, which is the most common form of dementia and causes patients to suffering mood swings, memory loss and confusion.

Professor Julie Williams' groundbreaking discovery means scientists are a step closer to pinpointing what goes wrong in Alzheimer's sufferer's brains and increases the prospect of developing treatment for the condition.

Professor Williams, of the University's MRC Centre for Neuropsychiatric Genetics and Genomics, said: "This study, plus our previous studies, means that we are beginning to piece together the pieces of the jigsaw and gain new understanding.

We still have a long way to go - but the jigsaw is beginning to come together.

"If we were able to remove the detrimental effects of these genes through treatments, we hope we can help reduce the proportion of people developing Alzheimer's in the longterm."

Published in Nature Genetics, the study of around 20,000 sufferers and 40,000 healthy individuals confirms that Alzheimer's disease remains a complex condition.

The scientists have been able to implicate a range of risk factors for the disease, including a sufferer's immune system, the ways the brain processes cholesterol and lipids and for the first time a process called endocytosis, which, in normal healthy brains removes toxic amyloid-beta protein from the brain.

Professor Williams said: "What's exciting is the genes we now know of, the five new ones, plus those previously identified, are clustering in patterns.

"So several genes are implicating the immune system, for example, and it's telling us there's something different about the immune system of people who go on to develop Alzheimer's disease. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items

Items saved from this article

This article has been saved
Highlights (0)
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

Citations (0)
Some of your citations are legacy items.

Any citation created before July 30, 2012 will labeled as a “Cited page.” New citations will be saved as cited passages, pages or articles.

We also added the ability to view new citations from your projects or the book or article where you created them.

Notes (0)
Bookmarks (0)

You have no saved items from this article

Project items include:
  • Saved book/article
  • Highlights
  • Quotes/citations
  • Notes
  • Bookmarks
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Cited article

Gene Discovery Brings Hope on Alzheimer's; CARDIFF SCIENTISTS FIND CAUSE OF INCREASED RISK OF DISEASE
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.