Effects of Low Doses of Bisphenol a on the Metabolome of Perinatally Exposed CD-1 Mice

By Cabaton, Nicolas J.; Canlet, Cecile et al. | Environmental Health Perspectives, May 2013 | Go to article overview

Effects of Low Doses of Bisphenol a on the Metabolome of Perinatally Exposed CD-1 Mice


Cabaton, Nicolas J., Canlet, Cecile, Wadia, Perinaaz R., Tremblay-Franco, Marie, Gautier, Roselyne, Molina, Jerome, Sonnenschein, Carlos, Cravedi, Jean-Pierre, Rubin, Beverly S., Soto, Ana M., Zalko, Daniel, Environmental Health Perspectives


Bisphenol A (BPA) is manufactured at a rate of > 3.1 million tons/year; thus, exposure to this compound is ubiquitous. Its possible impact on human health is reflected in recent worldwide regulatory legislation. For example, the Canadian authorities, followed by the European Union, have recently banned the use of BPA in infant feeding bottles, a landmark move to safeguard the health of infants and the general population (Asimakopoulos et al. 2012; European Commission 2011). Nevertheless, BPA is still widely used in polycarbonates, epoxy resins, paints, lacquers, and medical devices. BPA is also used as a base compound for the manufacture of flame retardants, brake fluids, and thermal papers (Fernandez et al. 2007). BPA monomers migrate out of these products and contaminate, for example, food, beverages, and intravenous infusions, (Goodson et al. 2004). Although the main route of contamination is through ingestion, the transdermal route could also contribute to BPA exposure in humans when direct contact with BPA (free monomer) occurs (Zalko et al. 2011). Detectable levels of BPA were present in urine samples of > 92% of Americans tested in the 2003-2004 National Health and Nutrition Examination Survey (Calafat et al. 2008). Higher exposure levels were found in children and adolescents compared with adults. Of particular concern is the finding of high levels of BPA in premature infants being treated in neonatal intensive care units (Calafat et al. 2009). BPA has also been detected in maternal and fetal plasma, in human placenta, and in the milk of nursing mothers (Calafat et al. 2006; Sun et al. 2004). Animal studies have highlighted the estrogenic effects of BPA (vom Saal et al. 2007), although BPA is considered by some to be a weak estrogen due to its low potency compared with estradiol in reporter gene assays involving nuclear receptors (Blair et al. 2000). However, recent work has shown that BPA can be as potent as or more potent than estradiol in promoting some estrogenic activities (Alonso-Magdalena et al. 2006, 2012). BPA can also bind to membrane receptors (G protein-coupled receptor 30 and the membrane form of estrogen receptor-[alpha]) to produce effects similar to those of estradiol (Thomas and Dong 2006; Welshons et al. 2006; Wozniak et al. 2005).

Perinatal BPA exposure has been reported to decrease fertility and fecundity in female CD-1 mice (Cabaton et al. 2011) and to decrease fertility in male offspring of exposed rats (Salian et al. 2011). Additional effects of perinatal BPA exposure include masculinization of behaviors and brain structures in female CD-1 mice (Richter et al. 2007; Rubin et al. 2006). Exposure to BPA through placenta and milk has been shown to increase early adipose storage and adipogenesis in a sex-specific and dose-dependent manner in rats and mice, with consequences on body weight later in life (Rubin and Soto 2009; Somm et al. 2009). BPA exposure has been linked to altered glucose homeostasis in pregnant female rodents and their male offspring (Alonso-Magdalena et al. 2010) and has been postulated to be a contributing factor in predisposing populations to the development of obesity and diabetes later in life (Heindel and vom Saal 2009; vom Saal et al. 2012).

The aim of metabonomics is to measure the "global, dynamic metabolic response of living systems to biological stimuli" (Nicholson and Lindon 2008). Metabolomics have furthered our understanding of drug toxicology while complementing more traditional approaches (Coen 2010). The integration of metabolomics and conventional toxicological studies is expected to provide valuable information for risk assessment of endocrine disruptors (EDs) such as BPA. Metabolic fingerprints based on nuclear magnetic resonance (NMR) spectroscopy, combined with appropriate statistical methods, could detect slight changes in the metabolome of cells, tissues, or organisms exposed to EDs, opening the way to examine whether exposure to an ED results in global alterations of metabolism and whether these changes persist after cessation of exposure. …

The rest of this article is only available to active members of Questia

Already a member? Log in now.

Notes for this article

Add a new note
If you are trying to select text to create highlights or citations, remember that you must now click or tap on the first word, and then click or tap on the last word.
One moment ...
Default project is now your active project.
Project items
Notes
Cite this article

Cited article

Style
Citations are available only to our active members.
Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

(Einhorn, 1992, p. 25)

(Einhorn 25)

(Einhorn 25)

1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

Note: primary sources have slightly different requirements for citation. Please see these guidelines for more information.

Cited article

Effects of Low Doses of Bisphenol a on the Metabolome of Perinatally Exposed CD-1 Mice
Settings

Settings

Typeface
Text size Smaller Larger Reset View mode
Search within

Search within this article

Look up

Look up a word

  • Dictionary
  • Thesaurus
Please submit a word or phrase above.
Print this page

Print this page

Why can't I print more than one page at a time?

Help
Full screen
Items saved from this article
  • Highlights & Notes
  • Citations
Some of your highlights are legacy items.

Highlights saved before July 30, 2012 will not be displayed on their respective source pages.

You can easily re-create the highlights by opening the book page or article, selecting the text, and clicking “Highlight.”

matching results for page

    Questia reader help

    How to highlight and cite specific passages

    1. Click or tap the first word you want to select.
    2. Click or tap the last word you want to select, and you’ll see everything in between get selected.
    3. You’ll then get a menu of options like creating a highlight or a citation from that passage of text.

    OK, got it!

    Cited passage

    Style
    Citations are available only to our active members.
    Buy instant access to cite pages or passages in MLA 8, MLA 7, APA and Chicago citation styles.

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn, 1992, p. 25).

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences." (Einhorn 25)

    "Portraying himself as an honest, ordinary person helped Lincoln identify with his audiences."1

    1. Lois J. Einhorn, Abraham Lincoln, the Orator: Penetrating the Lincoln Legend (Westport, CT: Greenwood Press, 1992), 25, http://www.questia.com/read/27419298.

    Cited passage

    Thanks for trying Questia!

    Please continue trying out our research tools, but please note, full functionality is available only to our active members.

    Your work will be lost once you leave this Web page.

    Buy instant access to save your work.

    Already a member? Log in now.

    Search by... Author
    Show... All Results Primary Sources Peer-reviewed

    Oops!

    An unknown error has occurred. Please click the button below to reload the page. If the problem persists, please try again in a little while.